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Glucagon

Class:
  • Pancreatic Hormone
  • Insulin Antagonist
Route:
  • IM or subcutaneous for hypoglycemia
  • IM or slow IV push (over 2-5 minutes) for bradycardia due to beta-blocker or calciumchannel blocker toxicity
  • Rapid IV push for cardiac arrest due to beta-blocker or calcium-channel toxicity
  • Intranasal (IN) rapid push as an alternative route when other routes are inaccessible

Adult Dose:

Hypoglycemia

  • 1 mg - standing order
  • If no response, BioTel may authorize additional doses at 15 minute intervals, if necessary

Bradycardia (beta-blocker toxicity)

  • 1 mg – 5 mg – standing order
  • 1 mg IM if IV or IO access not available

Cardiac arrest (beta-blocker toxicity)

  • 1 mg – 5 mg - standing order

Pediatric Dose
    1 - 12 years

  • Hypoglycemia
  • 1 mg - standing order
  • If no response, BioTel may authorize additional doses at 15 minute intervals if necessary
  • Beta-blocker toxicity
  • 1mg - BIOTEL AUTHORIZATION ONLY
Pediatric Dose
   less than 1 year
  • Hypoglycemia
  • 0.5 mg - standing order
Drug Action:
  • Converts stored glycogen to glucose, increasing blood glucose levels
  • Improves cardiac contractility and increases heart rate
Onset: Within 1 minute, however it may be 15 minutes before any response is observed
Duration: 60 - 90 minutes
Indications:
  • Hypoglycemia when no IV is obtainable and gag reflex is absent (should not be considered a first-line choice for hypoglycemia)
  • Beta blocker and calcium channel blocker toxicity
Precautions:

Administer cautiously to:

  • Patients with cardiovascular disease
  • Patients with kidney or liver dysfunction
Side Effects:
  • Hypotension
  • Nausea
  • Vomiting
  • Tachycardia
Contraindications: Hypersensitivity to proteins

 

 

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