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Amiodarone HCL (Cordarone®)

Class: Antiarrhythmic
Route: IV or IO push only

Adult Dose:

Ventricular fibrillation; pulseless ventricular tachycardia

  • First Dose - 300 mg - standing order
  • Second Dose - 150 mg - standing order

Stable or unstable, sustained ventricular tachycardia with pulse

  • 150 mg - over 10 minutes - BIOTEL AUTHORIZATION ONLY
Pediatric Dose:

Ventricular fibrillation; pulseless ventricular tachycardia; stable, unstable, sustained, or non-sustained ventricular tachycardia with a pulse

  • 5 mg/kg in 100 ml NS slow push over 30 minutes - BIOTEL AUTHORIZATION ONLY
Drug Action:
  • Alters movement of sodium, potassium and calcium through normal channels thereby
    • Increasing the refractory period of all cardiac tissues
    • Slowing repolarization
    • Decreasing automaticity
  • Alpha and beta blocker
Onset: Within minutes
Duration: Variable
Indications:
  • Ventricular fibrillation or pulseless ventricular tachycardia that does not respond to initial defibrillation attempts
  • Sustained ventricular tachycardia with a pulse
Precautions:
  • Do not shake (prevents foaming); draw-up with large gauge needle
  • Protect from light
  • Avoid contact with plastic; administer at closest IV port
  • Use with caution in renal failure patients
Side Effects:
  • Bradycardia
  • Hypotension
Contraindications: Trauma patients

 

 

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